Specificity, versatility, and control of TGF-β family signaling
نویسندگان
چکیده
منابع مشابه
Specificity and Versatility in TGF-β Signaling Through Smads
The TGF-β family comprises many structurally related differentiation factors that act through a heteromeric receptor complex at the cell surface and an intracellular signal transducing Smad complex. The receptor complex consists of two type II and two type I transmembrane serine/threonine kinases. Upon phosphorylation by the receptors, Smad complexes translocate into the nucleus, where they coo...
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Transforming growth factor β (TGF-β) family members signal via heterotetrameric complexes of type I and type II dual specificity kinase receptors. The activation and stability of the receptors are controlled by posttranslational modifications, such as phosphorylation, ubiquitylation, sumoylation, and neddylation, as well as by interaction with other proteins at the cell surface and in the cytop...
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THE TRANSFORMING GROWTH FACTOR-β (TGF-β) FAMILY is critically involved in the development and maintenance of skeletal tissues. In searches for factors with potent cartilage and bone inductive activities, TGF-β was isolated as cartilage-inducing factor (Seyedin et al. 1987), whereas bone morphogenetic proteins (BMPs) were isolated as factors able to induce cartilage and bone formation (Urist 196...
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TGF-β superfamily ligands play fundamental roles in the development and physiology of diverse animal species. Genetic and genomic analyses in the model organism Caenorhabditis elegans have contributed to the understanding of TGF-β-related signal transduction mechanisms. In this chapter, I describe the currently characterized TGF-β-related signals and signal transduction cassettes in C. elegans....
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ژورنال
عنوان ژورنال: Science Signaling
سال: 2019
ISSN: 1945-0877,1937-9145
DOI: 10.1126/scisignal.aav5183